City of Hope (http://www.cityofhope.org) is a National Cancer Institute-designated Comprehensive Cancer Center known for compassionate care and innovative research. Within City of Hope lies the Beckman Research Institute which has advanced breakthroughs in scientific discovery for 25 years. The research team of Dr. Leslie Bernstein at the Beckman Research Institute serves as experts in the fields of epidemiology and the conduct of cohort studies for HOW. Their collaboration will ensure that the HOW Study is able to obtain valuable and useful data. With their assistance in designing the study, analyzing the data, and disseminating the results of our analyses, we hope to answer many current and important questions about your health.